The Best PDGF-AA Products

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PDGF-AA Recombinant Protein

The best Recombinant Protein, Recombinant Murine and other products, quick delivery, high quality.

Product description

Below is a list of the details of this product.

Product price:

682.50

Product size:

0.002 mg, 0.01 mg

Product catalog no.:

40-157

Product description

Below is a list of the details of this product.

NCBI ID

5154

Protein's origin

Human

Uniprot

P04085

Recombinant in

E. coli

Rec. PROTEIN GI#

77695917

Vial

Lyophilized

Accession nr

NP_002598.4

Group

recombinants

Source

Homo sapiens

Additional source

Recombinants or rec. proteins

About

This product is for research use only.

Gene name

platelet-derived growth factor alpha polypeptide

Other name of the recombinant

PDGF1, PDGF-A, PDGF1, Platelet-derived growth factor subunit A, PDGF-1, PDGF subunit A

Pureity

Greater than 98% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg).

SEQUENCE

SIEEAVPAVC KTRTVIYEIP RSQVDPTSAN FLIWPPCVEV KRCTGCCNTS SVKCQPSRVH HRSVKVAKVE YVRKKPKLKE VQVRLEEHLE CACATTSLNP DYREEDTGRP RESGKKRKRK RLKPT

Activity

The ED50 was Biological activity was determined by the dose - dependent stimulation of thymidine uptake by Balb/c 3T3 cells is ≤ 1 ng/mL, corresponding to a specific activity of ≥ 1 x 106 units/mg.

Keep at

The lyophilized PDGF-AA recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted PDGF-AA is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing PDGF-AA recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

About recombinant protein

PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-AA is a 28.5 kDa disulfide-linked homodimer of two A chains (250 total amino acids).

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